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Stem cells: a brief history and outlook

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❶Science Progress June 15, Robert Streiffer, a bioethicist at the University of Wisconsin-Madison, publishes a paper detailing his investigation into the consent forms for the federally approved human embryonic stem cell lines.

June 2013: Pluripotent Stem Cells Derived from Cloned Human Embryos

July 2013: Human Liver Created from Stem Cells
History of Stem Cell Research | Understanding the Timeline
Opening the lines of communication between research scientists and the wider community

Andrew Lassar and Harold Weintraub of Seattle, Washington, report results from an experiment in which they converted rodent fibroblasts a type of connective tissue directly into myoblasts which generate muscle cells , using a single gene MyoD. Being able to convert one type of adult cell into another may be important for regenerative medicine. Researchers Mario Capecchi, Martin Evans and Oliver Smithies come together to creat the first "knockout" mice from a combination of embryonic stem cells and homologous recombination, a process in which similar strands of DNA switch genes.

These mice were bred to be missing certain genetic sequences. Since the first patients, over mouse analogs of human disease have been made. Dominique Bonnet and John Dick of Canada discover that leukemia comes from the same stem cells that make our blood cells. A team at the University of Wisconsin, Madison, led by James Thomson and Jeffrey Jones, reports the creation of the first batch of human embryonic stem cells, which they derived from early embryos. After finding the cells were pluripotent, the team sees the potential the cells have for drug discovery and transplantation medicine.

Daley and his team publish findings on converting stem cells from mice into germ cells and, eventually, primitive sperm cells that are able to fertilize egg cells. These embryonic germ cells give scientists a chance to study different processes, including cancer growth and the development of sperm cells.

Claudia Castillo becomes the first woman to have an organ grown from her own stem cells transplanted into herself. In this case, it is her windpipe. This was the first FDA approval of a clinical trial for a therapy based on human embryonic stem cells.

Meet Kirsten Historical Comaprison. Apartheid South Africa Legislative Laws ECE History and Philosophy: Hechos historicos de la historia de Puerto Rico. Scientific Discoveries of the 's. The President claims that more than 60 stem cell lines are still available for funding.

Research on adult stem cells is not affected by this executive order. However, the bill is quickly vetoed by President Bush.

The House votes in favor of the bill, but the two-thirds majority needed to override the veto is not reached. The House also passes the Senate's version of the bill Again, the bill is vetoed by President Bush, and again Congress cannot override the veto.

A group of plaintiffs led by adult stem cell scientists James Sherley, M. The case was brought up against Kathleen Sebelius, the U. Secretary of Health and Human Services at that time. Court of Appeals for the D. Circuit] reasoning and conclusions, must find that defendants reasonably interpreted the Dickey-Wicker Amendment to permit funding for human embryonic stem cell research because such research is not 'research in which a human embryo or embryos are destroyed' That policy question is not answered by any congressional law, and it has fallen on three presidential administrations to provide an answer.

For all three such administrations, Democratic and Republican, the answer has been to permit federal funding. They have differed only as to the path forward. See the full text of the ruling here. Researchers at Cedars-Sinai Medical Center and Johns Hopkins University publish results from a clinical trial in which adult stem cells were extracted from patients following a heart attack.

In the first demonstrated case of therapeutic regeneration, the treatment decreases scarring and leads to regrowth of heart tissue. In a decision favorable to proponents of ES cell research, the U. Sebelius , thereby upholding the previous ruling of the D. By removing the DNA from an egg cell and replacing it with genetic material from a skin cell, scientists create stem cells that can be programmed into becoming many different cell types, including the contracting cardiomyocytes that make up our heart muscle.


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The information used to compile this Stem Cell Research Timeline comes from many different sources, including the National Institutes of Health. A useful list of links to other stem cell research timelines from around the Web can be found at the bottom of this page.

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This timeline takes you through the ups and downs of the stem cell rollercoaster. , Mouse beginnings Martin Evans of Cardiff University, UK, then at the University of Cambridge, is first to identify embryonic stem cells – in mice.

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History of Stem Cell Research — A Timeline Wrights/Giemsa stained human embryonic stem cell (hESC) colony on murine embryonic fibroblast feeder cells. The colony contains roughly individual hESCs. From early fetal tissue research to the first successful human treatments, this timeline documents the progress in stem cell science, and the policies that have impeded or promoted it. The stories of research involving human embryonic stem cells and the policy governing that work are intertwined and stretch back into the mids.

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Stem cells have been used in medicine since the ’s when bone marrow transplants were first used to treat leukemia. Congressional involvement in stem cell policy started as early as The first major amendment related to the use of federal funds for research involving embryonic stem (ES) cells occurred in The history of stem cell research, a timeline made with Timetoast's free interactive timeline making software.